Ventricular tachyarrhythmias prediction in patients with coronary artery disease and left ventricular dysfunction

Abstract Funding Acknowledgements Type of funding sources: None. Introduction. The cardioverter-defibrillator (ICD) implantation is the most effective method for sudden cardiac death (SCD) prevention. However, about 25% patients didn"t have an incidence ICD shocks during first battery life. Most them are mainly represented by who had implanted primary prevention SCD. It us known, reduced left ventricular ejection fraction (LVEF) independent predictor So, it’s necessary to find out new predictors SCD and arrhythmias (VTA) incidence, which will help optimize selection really need a implantation. Purpose. To identify predicting methods VTA in with coronary artery disease LVEF 35% or less. Materials methods. study included 40 (males – 36, mean age 63,4 ± 7,8 years) (CAD), less indications (primary SCD). Patients before underwent 6-minute walk test, echocardiography, heart rate variability analysis single-photon emission computed tomography 123I-meta-iodobenzylguanidine (123I-MIBG). All after were followed-up two years divided into groups. Results. 1-st group consisted 36 (90,0%) events. 2-nd 4 (10,0%) without univariate ROC-analysis showed that low values average NN intervals (AUC = 0,986, p 0,0001, t ? 1211 ms), standard deviation 119 0,861, 94 0,792, 0,004, 48 root square successive differences 0,847, 0,0003, 18 very frequency domain 0,02, 2411 (LFD) 0,903, 1046 high 0,875, 743 total domains 2785 heart/mediastinum ratio on early 0,889, 2,29) delayed 0,806, 0,001, 1,65) scintigrams, as well end-diastolic index 0,944, > 65,9 ml/m2), end-systolic 1,000, 23,6 ??/?2), 123I-MIBG accumulation defect 0,958, 15,0%) 18,0%) scintigrams leaded frequent occurrences VTA. multivariate demonstrated LFD (p 0,0136) Also, increase predictive ratio, calculated according this model, more than 0,8936 0,0001). Conclusion. A decrease can be CAD. An prognostic marker life-threatening arrhythmias.